Cd274^tm1Yayi
Targeted Allele Detail

Summary

• Symbol: Cd274^tm1Yayi
• Name: CD274 antigen; targeted mutation 1, Yiping Yang
• MGI ID: MGI:7428395
• Synonyms: Pdl1^fl
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^tm1Yayi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322274
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. (J:322274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 71 strains or lines available

References

• Original: J:322274 Petty AJ, et al., Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function. JCI Insight. 2021 Mar 22;6(6)
• All: 1 reference(s)