Shank3^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Shank3^tm1.1Ics
• Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7428383
• Synonyms: Shank3^Venus
• Gene: Shank3 Location: Chr15:89383826-89444464 bp, + strand Genetic Position: Chr15, 44.96 cM
• Alliance: Shank3^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332650
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Modified isoform(s), Reporter)
• Mutation: Insertion
• Mutation details: The targeted vector with an auto-excision floxed Neomycin resistance cassette and a 1.5 kb fragment corresponding to the fusion of the Venus tag sequence at the beginning of exon1 of the Shank3 gene, just after the ATG start codon was inserted. The floxed selection cassette was excised in the germline chimera mice. The reporter is to tag exclusively the endogenous Shank3 variants that are produced by the first promoter: variants of the Shank3a isoform only. (J:332650)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank3 Mutation: 87 strains or lines available

References

• Original: J:332650 Bouquier N, et al., The Shank3(Venus/Venus) knock in mouse enables isoform-specific functional studies of Shank3a. Front Neurosci. 2022;16:1081010
• All: 1 reference(s)