Arf6^tm1.1Sjod
Targeted Allele Detail

Summary

• Symbol: Arf6^tm1.1Sjod
• Name: ADP-ribosylation factor 6; targeted mutation 1.1, Shannon J Odelberg
• MGI ID: MGI:7427864
• Gene: Arf6 Location: Chr12:69418924-69420557 bp, + strand Genetic Position: Chr12, 28.81 cM
• Alliance: Arf6^tm1.1Sjod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328460
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 5 of the gene at position 69,371,642 and second loxP site 3 of the open reading frame at position 67,373,928. Cre-mediated recombination deleted the floxed region. (J:328460)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arf6 Mutation: 10 strains or lines available

References

• Original: J:328460 Zhu W, et al., Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy. J Clin Invest. 2017 Dec 1;127(12):4569-4582
• All: 1 reference(s)