Mapt^tm1.1Godt
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1.1Godt
• Name: microtubule-associated protein tau; targeted mutation 1.1, Michel Goedert
• MGI ID: MGI:7427520
• Synonyms: Mapt^P290S
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1.1Godt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332555
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting construct was designed to insert S290 into exon 10 of Mapt, the murine tau gene, by homologous recombination. The Neo-loxP selection cassette was removed by crossing with mice that express Cre recombinase. The murine tau with the P290S mutation is equivalent to human P301S tau. (J:332555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:332555 Huang M, et al., Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App (NL-G-F) Mice. eNeuro. 2022 Nov-Dec;9(6):ENEURO.0247-22.2022
• All: 1 reference(s)