Auts2^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Auts2^tm1.1Bcgen
• Name: autism susceptibility candidate 2; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7427466
• Synonyms: Auts2^fl
• Gene: Auts2 Location: Chr5:131466171-132572059 bp, - strand Genetic Position: Chr5, 70.66 cM, cytoband G1
• Alliance: Auts2^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331537
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6 and an FRT-flanked neomycin resistance cassette and second loxP site were inserted downstream of exon 6. The neomycin cassette was removed via flp-mediated recombination leaving exon 6 floxed. (J:331537)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Auts2 Mutation: 64 strains or lines available

References

• Original: J:331537 Li J, et al., Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms. Sci Adv. 2022 Mar 4;8(9):eabk1238
• All: 1 reference(s)