Btla^tm1.1Kro
Targeted Allele Detail

Summary

• Symbol: Btla^tm1.1Kro
• Name: B and T lymphocyte associated; targeted mutation 1.1, Mitchell Kronenberg
• MGI ID: MGI:7427371
• Gene: Btla Location: Chr16:45043121-45073258 bp, + strand Genetic Position: Chr16, 29.52 cM
• Alliance: Btla^tm1.1Kro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324910
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 4 and a loxP ste was inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:324910)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Btla Mutation: 29 strains or lines available

References

• Original: J:324910 Stienne C, et al., Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa. Cell Rep. 2022 Mar 22;38(12):110553
• All: 2 reference(s)