Vwf^tm1.1Suzu
Targeted Allele Detail

Summary

• Symbol: Vwf^tm1.1Suzu
• Name: Von Willebrand factor; targeted mutation 1.1, Nobuaki Suzuki
• MGI ID: MGI:7425429
• Synonyms: Vwf-K1362A
• Gene: Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vwf^tm1.1Suzu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325044
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted upstream of exon 28 and a K1362A was inserted in exon 28 via homologous recombination. Cre mediated recombination removed the neo cassette. Expression of RNA in the heart, liver, and lung from homozygous mice was 7% that of wild-type. (J:325044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vwf Mutation: 139 strains or lines available

References

• Original: J:325044 Sanda N, et al., Vwf K1362A resulted in failure of protein synthesis in mice. Int J Hematol. 2018 Apr;107(4):428-435
• All: 1 reference(s)