Del(6Rr147611)3Pike
Endonuclease-mediated Allele Detail
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Symbol: |
Del(6Rr147611)3Pike |
Name: |
deletion, Chr 6, J Wesley Pike 3 |
MGI ID: |
MGI:7425279 |
Synonyms: |
Fgf23-16KO, FGF23-16KO |
Gene: |
Del(6Rr147611)3Pike Location: unknown Genetic Position: Chr6, Syntenic
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Strain of Origin: |
Not Applicable
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Allele Type: |
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Endonuclease-mediated (Modified regulatory region) |
Mutation: |
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Intergenic deletion
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Del(6Rr147611)3Pike involves 1 genes/genome features (Rr147611)
View all
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Mutation details: An Fgf23 bone enhancer, located ~16 kb upstream, was targeted with sgRNAs (targeting GGAGGCGTAAACATCTGATCAGG and CCATGGGCTAGGGTGCGGAATGG) using CRISPR/Cas9 technology, resulting in a 947 bp deletion. The deleted sequence contains putative enhancer Rr147611.
(J:281531)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(6Rr147611)3Pike Mutation: |
0 strains or lines available
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Original: |
J:281531 Lee SM, et al., A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In Vivo. Endocrinology. 2019 Dec 1;160(12):2877-2891 |
All: |
2 reference(s) |
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