Trpv4^tm1.1Sumn
Targeted Allele Detail

Summary

• Symbol: Trpv4^tm1.1Sumn
• Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1.1, Charlotte Sumner
• MGI ID: MGI:7425160
• Gene: Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Trpv4^tm1.1Sumn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322066
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a loxP site and FRT-flanked pgk-neo cassette were inserted downstream of exon 5 via homologous recombination. Flp-mediated recombination removed the pgk-neo cassette. (J:322066)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv4 Mutation: 60 strains or lines available

References

• Original: J:322066 Dupont C, et al., TRPV4 Antagonism Prevents Mechanically Induced Myotonia. Ann Neurol. 2020 Aug;88(2):297-308
• All: 1 reference(s)