Rapgef3^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Rapgef3^tm1.2Geno
• Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1.2, Genoway
• MGI ID: MGI:7425123
• Gene: Rapgef3 Location: Chr15:97642651-97665853 bp, - strand Genetic Position: Chr15, 53.74 cM
• Alliance: Rapgef3^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 3-6. (J:182701, J:311958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef3 Mutation: 45 strains or lines available

References

• Original: J:311958 He X, et al., Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis. Life Sci. 2019 Mar 15;221:1-12
• All: 3 reference(s)