Kcnq2^em2Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnq2^em2Smoc
• Name: potassium voltage-gated channel, subfamily Q, member 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7425036
• Synonyms: Kcnq2-R207W, Kcnq2^RW
• Gene: Kcnq2 Location: Chr2:180717372-180777093 bp, - strand Genetic Position: Chr2, 103.57 cM, cytoband H3-4
• Alliance: Kcnq2^em2Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of arginine with tryptophan at position 207 (R207W). (J:329986)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq2 Mutation: 49 strains or lines available

References

• Original: J:329986 Tian F, et al., Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation. Neurobiol Dis. 2022 Sep 14;174:105860
• All: 1 reference(s)