Rpl10^tm1.1Pg
Targeted Allele Detail

Summary

• Symbol: Rpl10^tm1.1Pg
• Name: ribosomal protein L10; targeted mutation 1.1, PolyGene AG
• MGI ID: MGI:7424899
• Synonyms: Rpl10^{cKI R98S}
• Gene: Rpl10 Location: ChrX:73314463-73316741 bp, + strand Genetic Position: ChrX, 37.94 cM
• Alliance: Rpl10^tm1.1Pg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271342
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Single point mutation
• Mutation details: Exons 5 to 7 were flanked by loxP sites and an FRT-flanked selection cassette was inserted upstream of the second loxP site (downstream of exon 7). Downstream of the floxed region, exon 5 containing an arginine to serine substitution at amino acid 98 (p.R98S) was inserted. Prior to cre recombination, the wild-type gene is expressed. Cre-mediated recombination can be used to remove the floxed region which results in expression of the mutant protein. The selection cassette was removed via flp-mediated recombination. (J:271342)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpl10 Mutation: 8 strains or lines available

References

• Original: J:271342 Girardi T, et al., The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. Leukemia. 2018 Mar;32(3):809-819
• All: 2 reference(s)