Pparg^tm1.1Qia
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.1Qia
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Li Qiang
• MGI ID: MGI:7424895
• Synonyms: Pparg^2KR
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.1Qia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312317
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A cDNA encoding for exons 5 - 7 plus the UTR replaced a genomic region including all of exon 5. In the cDNA, exons 5 and 6 contain K to R substitutions at positions 268 and 293 (K268R, K293R). In addition, a floxed neo selection cassette was inserted downstream of the cDNA then removed via cre-mediated recombination. (J:312317)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 42 strains or lines available

References

• Original: J:312317 Kraakman MJ, et al., PPARgamma deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects. J Clin Invest. 2018 Jun 1;128(6):2600-2612
• All: 4 reference(s)