St8sia2^tm2546.1Arte
Targeted Allele Detail

Summary

• Symbol: St8sia2^tm2546.1Arte
• Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; targeted mutation 2546.1, TaconicArtemis
• MGI ID: MGI:7424846
• Synonyms: St8sia2^f
• Gene: St8sia2 Location: Chr7:73588867-73663408 bp, - strand Genetic Position: Chr7, 42.27 cM
• Alliance: St8sia2^tm2546.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287871
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exon 4 and an FRT-flanked neo cassette was inserted in intron 3. Flp-mediated recombination removed the neo cassette leaving exon 4 floxed. (J:287871)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St8sia2 Mutation: 23 strains or lines available

References

• Original: J:287871 Schuster UE, et al., Cell-autonomous impact of polysialic acid-producing enzyme ST8SIA2 on developmental migration and distribution of cortical interneurons. J Neurochem. 2020 Feb;152(3):333-349
• All: 2 reference(s)