Sirt2^tm1.2Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt2^tm1.2Cxd
• Name: sirtuin 2; targeted mutation 1.2, Chu-Xia Deng
• MGI ID: MGI:7424799
• Synonyms: Sirt2^fl
• Gene: Sirt2 Location: Chr7:28466192-28488086 bp, + strand Genetic Position: Chr7, 16.92 cM, cytoband B1-2
• Alliance: Sirt2^tm1.2Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273975
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked neomycin gene was inserted upstream of exon 5 and a third loxP site was inserted downstream of exon 8. The neomycin gene was removed via cre-mediated recombination leaving exons 5-8 floxed. (J:177486, J:273975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt2 Mutation: 29 strains or lines available

References

• Original: J:273975 Song HY, et al., SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status. Oncotarget. 2016 Dec 6;7(49):80336-80349
• All: 3 reference(s)