Scnn1g^tm1.1Tkl
Targeted Allele Detail

Summary

• Symbol: Scnn1g^tm1.1Tkl
• Name: sodium channel, nonvoltage-gated 1 gamma; targeted mutation 1.1, Thomas R Kleyman
• MGI ID: MGI:7423808
• Gene: Scnn1g Location: Chr7:121333702-121367698 bp, + strand Genetic Position: Chr7, 65.07 cM
• Alliance: Scnn1g^tm1.1Tkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332351
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 3. Germ line, flp-recombination was used to remove the neo cassette. (J:332351)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scnn1g Mutation: 34 strains or lines available

References

• Original: J:332351 Mutchler SM, et al., Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury. Int J Mol Sci. 2021 Oct 9;22(20)
• All: 1 reference(s)