Scn5a^em1Vmc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn5a^em1Vmc
• Name: sodium channel, voltage-gated, type V, alpha; endonuclease-mediated mutation 1, Vincent M Christoffels
• MGI ID: MGI:7423721
• Synonyms: Scn5a^delta7
• Gene: Scn5a Location: Chr9:119312474-119408082 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Scn5a^em1Vmc page

Mutation origin

• Strain of Origin: FVB/NRj

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was targeted with TALENs, resulting in a 7 bp deletion that leads to a frameshift and premature stop codon. (J:281596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn5a Mutation: 104 strains or lines available

References

• Original: J:281596 Man JCK, et al., An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Nat Commun. 2019 Oct 30;10(1):4943
• All: 1 reference(s)