Prss3b^tm4.1Satom
Targeted Allele Detail

Summary

• Symbol: Prss3b^tm4.1Satom
• Name: serine protease 3B; targeted mutation 4.1, Miklos Sahin-Toth
• MGI ID: MGI:7414396
• Synonyms: T7G199R
• Gene: Prss3b Location: Chr6:41007202-41012443 bp, - strand Genetic Position: Chr6, 19.1 cM
• Alliance: Prss3b^tm4.1Satom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331941
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A G to C change at position 595 (c.595G>C) resulting in a glycine to arginine substitution at amino acid 199 (p.G199R) was introduced in exon 5 via homologous recombination. A loxP-flanked neomycin cassette was inserted in intron 4 and was removed via cre-mediated recombination. (J:331941)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss3b Mutation: 24 strains or lines available

References

• Original: J:331941 Mosztbacher D, et al., Mouse model suggests limited role for human mesotrypsin in pancreatitis. Pancreatology. 2021 Mar;21(2):342-352
• All: 1 reference(s)