Trpv4^tm1.1Gai
Targeted Allele Detail

Summary

• Symbol: Trpv4^tm1.1Gai
• Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1.1, Philippe Gailly
• MGI ID: MGI:7414392
• Synonyms: Trpv4^lox
• Gene: Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Trpv4^tm1.1Gai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321993
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site, FRT flanked neo cassette, and second loxP site were inserted upstream of exon 6 and a third loxP site was inserted downstream of exon 6 via homologous recombination. (J:321993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv4 Mutation: 60 strains or lines available

References

• Original: J:321993 Gualdani R, et al., Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells. Sci Signal. 2020 Oct 13;13(653)
• All: 3 reference(s)