Hdac3^tm1.1Juch
Targeted Allele Detail

Summary

• Symbol: Hdac3^tm1.1Juch
• Name: histone deacetylase 3; targeted mutation 1.1, Jun Chen
• MGI ID: MGI:7414275
• Synonyms: HDAC3^loxP
• Gene: Hdac3 Location: Chr18:38070024-38088073 bp, - strand Genetic Position: Chr18, 19.81 cM, cytoband B3
• Alliance: Hdac3^tm1.1Juch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330787
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance cassette with a 5' loxP site downstream of exon 3. Flp-mediated recombination removed the selection cassette. (J:330787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac3 Mutation: 32 strains or lines available

References

• Original: J:330787 Zhao Y, et al., Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury. J Neuroinflammation. 2022 Aug 6;19(1):201
• All: 1 reference(s)