Siglech^em1Yliu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Siglech^em1Yliu
• Name: sialic acid binding Ig-like lectin H; endonuclease-mediated mutation 1, Yang Liu
• MGI ID: MGI:7413911
• Gene: Siglech Location: Chr7:55417926-55428673 bp, + strand Genetic Position: Chr7, 33.42 cM
• Alliance: Siglech^em1Yliu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 5 bp (p.Cys53ProfsTer55). (J:330795)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglech Mutation: 24 strains or lines available

References

• Original: J:330795 Wang X, et al., CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. Cell Metab. 2022 Aug 2;34(8):1088-1103.e6
• All: 1 reference(s)