Col1a1^tm1.1Kekk
Targeted Allele Detail

Summary

• Symbol: Col1a1^tm1.1Kekk
• Name: collagen, type I, alpha 1; targeted mutation 1.1, Kevin K Kim
• MGI ID: MGI:7413878
• Synonyms: Col1a1^f
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^tm1.1Kekk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202481
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin resistance gene and second loxP site were inserted downstream of exon 5. The neomycin resistance gene was removed via flp-mediated recombination leaving exons 2-5 floxed. (J:202481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

References

• Original: J:202481 Yang J, et al., Activated Alveolar Epithelial Cells Initiate Fibrosis through Secretion of Mesenchymal Proteins. Am J Pathol. 2013 Nov;183(5):1559-70
• All: 2 reference(s)