Ghrl^tm1.2Tolv
Targeted Allele Detail

Summary

• Symbol: Ghrl^tm1.2Tolv
• Name: ghrelin; targeted mutation 1.2, Virginie Tolle
• MGI ID: MGI:7413876
• Gene: Ghrl Location: Chr6:113693080-113696841 bp, - strand Genetic Position: Chr6, 52.84 cM, cytoband E3
• Alliance: Ghrl^tm1.2Tolv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217008
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette and exons 2 and 3. (J:217008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghrl Mutation: 12 strains or lines available

References

• Original: J:217008 Hassouna R, et al., An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth. Endocrinology. 2014 Sep;155(9):3561-71
• All: 4 reference(s)