Cdh13^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Cdh13^{tm1c(EUCOMM)Hmgu}
• Name: cadherin 13; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7413208
• Synonyms: Cdh13^loxP
• Gene: Cdh13 Location: Chr8:119010472-120051660 bp, + strand Genetic Position: Chr8, 65.97 cM
• Alliance: Cdh13^{tm1c(EUCOMM)Hmgu} page
• IMPC: Cdh13 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324955
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 119401336 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 119402216. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065, J:324955)

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh13 Mutation: 28 strains or lines available

References

• Original: J:324955 Rivero O, et al., Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition. Transl Psychiatry. 2015 Oct 13;5:e655
• All: 4 reference(s)