Tfrc^{tm1(TFRC)Takak}
Targeted Allele Detail

Summary

• Symbol: Tfrc^{tm1(TFRC)Takak}
• Name: transferrin receptor; targeted mutation 1, Kenichi Takahashi
• MGI ID: MGI:7413205
• Synonyms: TFRC-KI
• Gene: Tfrc Location: Chr16:32427738-32451612 bp, + strand Genetic Position: Chr16, 23.06 cM
• Alliance: Tfrc^{tm1(TFRC)Takak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326306
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Tfrc^{tm1(TFRC)Takak} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  mouse

  Tfrc (MGI:98822)

  transmembrane and intracellular domains

  human

  TFRC (7037)

  Tfrc	(MGI:98822)

  extracellular domain

• Mutation details: A construct containing a cDNA coding for a chimeric protein including the extracellular domain of human TRFC and the transmembrane and intracellular domains of mouse Tfrc followed by a floxed neo cassette was inserted in exon 2 via homologous recombination. (J:326306)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfrc Mutation: 64 strains or lines available

References

• Original: J:326306 Sonoda H, et al., A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II. Mol Ther. 2018 May 2;26(5):1366-1374
• All: 3 reference(s)