Foxp3^em1Doi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Foxp3^em1Doi
• Name: forkhead box P3; endonuclease-mediated mutation 1, Christophe Benoist
• MGI ID: MGI:7413167
• Synonyms: FoxP3^R337Q/Doi
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^em1Doi page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 11 introduced the nucleotide substitution GA to AG resulting in the amino acid substitution arginine with glutamine at position 337 (R337Q). (J:330817)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 55 strains or lines available

References

• Original: J:330817 Leng F, et al., The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. Immunity. 2022 Aug 9;55(8):1354-1369.e8
• All: 1 reference(s)