Tfeb^tm1.1Busf
Targeted Allele Detail

Summary

• Symbol: Tfeb^tm1.1Busf
• Name: transcription factor EB; targeted mutation 1.1, Federico Bussolino
• MGI ID: MGI:7413130
• Synonyms: Tfeb-GFP
• Gene: Tfeb Location: Chr17:48047962-48103341 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband D
• Alliance: Tfeb^tm1.1Busf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328468
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The open reading frame of EGFP was inserted between the last amino acid and the translation termination codon in exon 9 and an FRT-flanked puromycin selection cassette was inserted in intron 8 via homologous recombination. Flp mediated recombination removed the puromycin selection cassette. (J:328468)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfeb Mutation: 48 strains or lines available

References

• Original: J:328468 Doronzo G, et al., TFEB controls vascular development by regulating the proliferation of endothelial cells. EMBO J. 2019 Feb 1;38(3):e98250
• All: 2 reference(s)