Myt1l^tm1.1Ggu
Targeted Allele Detail

Summary

• Symbol: Myt1l^tm1.1Ggu
• Name: myelin transcription factor 1-like; targeted mutation 1.1, Guoqiang Gu
• MGI ID: MGI:7413108
• Synonyms: Myt1L^F
• Gene: Myt1l Location: Chr12:29578383-29973212 bp, + strand Genetic Position: Chr12, 11.86 cM
• Alliance: Myt1l^tm1.1Ggu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263864
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 12 and an FRT flanked neomycin resistance cassette with a 3' loxP site downstream of exon 12. Flp-mediated recombination removed the selection cassette. (J:263864)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myt1l Mutation: 71 strains or lines available

References

• Original: J:263864 Huang C, et al., Synaptotagmin 4 Regulates Pancreatic beta Cell Maturation by Modulating the Ca(2+) Sensitivity of Insulin Secretion Vesicles. Dev Cell. 2018 May 7;45(3):347-361.e5
• All: 1 reference(s)