Sik3^em9Iiis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sik3^em9Iiis
• Name: SIK family kinase 3; endonuclease-mediated mutation 8, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:7412960
• Synonyms: Sik3^Slp;T221A
• Gene: Sik3 Location: Chr9:45924118-46135492 bp, + strand Genetic Position: Chr9, 25.36 cM
• Alliance: Sik3^em9Iiis page

Mutation origin

• Strain of Origin: C57BL/6J-Sik3^Slp

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution threonine to alanine at position 221 (T221A). (J:332227)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik3 Mutation: 71 strains or lines available

Notes

This allele was generated in zygotes containing Sik3^Slp.

References

• Original: J:332227 Kim SJ, et al., Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature. 2022;612(7940):512-518
• All: 1 reference(s)