Tshr^tm1.1Elgad
Targeted Allele Detail

Summary

• Symbol: Tshr^tm1.1Elgad
• Name: thyroid stimulating hormone receptor; targeted mutation 1.1, Aziz Elgadi
• MGI ID: MGI:7411168
• Gene: Tshr Location: Chr12:91367767-91507283 bp, + strand Genetic Position: Chr12, 44.51 cM
• Alliance: Tshr^tm1.1Elgad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329174
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked pgk-neo cassette and loxP site were inserted upstream of exon 10 and a loxP site was inserted downstream of exon 10 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:329174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tshr Mutation: 10 strains or lines available

References

• Original: J:329174 Elgadi A, et al., Tissue-specific knockout of TSHr in white adipose tissue increases adipocyte size and decreases TSH-induced lipolysis. Biochem Biophys Res Commun. 2010 Mar 12;393(3):526-30
• All: 2 reference(s)