Ccr3^tm1.1Zhux
Targeted Allele Detail

Summary

• Symbol: Ccr3^tm1.1Zhux
• Name: C-C motif chemokine receptor 3; targeted mutation 1.1, XinHua Zhu
• MGI ID: MGI:7408572
• Gene: Ccr3 Location: Chr9:123822009-123831726 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr3^tm1.1Zhux page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332031
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:332031)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr3 Mutation: 30 strains or lines available

References

• Original: J:332031 Dai M, et al., CCR3 gene knockout in bone marrow cells ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing airway inflammatory cell infiltration and Th2 cytokines expression in mice model. Int Immunopharmacol. 2022 Mar;104:108509
• All: 2 reference(s)