Gata3^tm1.1Jfz
Targeted Allele Detail

Summary

• Symbol: Gata3^tm1.1Jfz
• Name: GATA binding protein 3; targeted mutation 1.1, Jinfang Zhu
• MGI ID: MGI:7408485
• Synonyms: Gata3 null
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm1.1Jfz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331971
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Homologous recombination was used to insert loxP sites surrounding exon 4, which encodes part of the zinc fingers important for DNA binding. Crossing with mice expressing Cre in the germline excised exon 4 and the floxed neo cassette from the inserted construct. (J:331971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 32 strains or lines available

References

• Original: J:331971 Martynova E, et al., Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3. Open Biol. 2019 Dec;9(12):190220
• All: 2 reference(s)