Rr328^tm1Mam
Targeted Allele Detail

Summary

• Symbol: Rr328^tm1Mam
• Name: regulatory region 328; targeted mutation 1, Lothar Hennighausen
• MGI ID: MGI:7408215
• Synonyms: GAS^deltaE1c
• Gene: Rr328 Location: Chr11:6589199-6589304 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr328^tm1Mam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: Four point mutations (T>A, A>G, C>T, C>G) were created in the interferonactivated sequence (GAS) motif and the NFIB- and ELF5-binding sites of the E1 enhancer (part of Wap super enhancer) upstream of Wap. (J:277922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr328 Mutation: 0 strains or lines available

References

• Original: J:277922 Shin HY, et al., Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet. 2016 Aug;48(8):904-911
• All: 1 reference(s)