Srsf2^tm2874.1Arte
Targeted Allele Detail

Summary

• Symbol: Srsf2^tm2874.1Arte
• Name: serine and arginine-rich splicing factor 2; targeted mutation 2874.1, TaconicArtemis
• MGI ID: MGI:7408195
• Synonyms: Srsf2^{tm2874(P95H)Arte}, Srsf2^tmP95H
• Gene: Srsf2 Location: Chr11:116740727-116743920 bp, - strand Genetic Position: Chr11, 81.49 cM
• Alliance: Srsf2^tm2874.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266284
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct inserted a second coding region with a modified exon 1 containing the mutation (CCG to CAT) encoding the amino acid substitution proline with histidine at position 95 (P95H). The endogenous coding region was flanked with loxP and FRT sites. Cre-mediated recombination removed the coding region. (J:266284)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srsf2 Mutation: 11 strains or lines available

References

• Original: J:266284 Smeets MF, et al., Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells. Blood. 2018 Aug 9;132(6):608-621
• All: 2 reference(s)