Cryba1^tm1.2Dbsa
Targeted Allele Detail

Summary

• Symbol: Cryba1^tm1.2Dbsa
• Name: crystallin, beta A1; targeted mutation 1.2, Debasish Sinha
• MGI ID: MGI:7408098
• Synonyms: Cryba1 KO
• Gene: Cryba1 Location: Chr11:77609441-77616109 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B-C1
• Alliance: Cryba1^tm1.2Dbsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251467
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 4 and 5 were deleted in the germline via Flp and Cre-mediated recombination. (J:251467)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cryba1 Mutation: 9 strains or lines available

References

• Original: J:251467 Valapala M, et al., betaA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes. Sci Rep. 2015 Mar 4;5:8755
• All: 2 reference(s)