Ube2o^tm1.1Xfu
Targeted Allele Detail

Summary

• Symbol: Ube2o^tm1.1Xfu
• Name: ubiquitin-conjugating enzyme E2O; targeted mutation 1, Xianghui Fu
• MGI ID: MGI:7407223
• Synonyms: Ube2o^fl
• Gene: Ube2o Location: Chr11:116428566-116472273 bp, - strand Genetic Position: Chr11, 81.42 cM
• Alliance: Ube2o^tm1.1Xfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin resistance gene were inserted upstream of exon 4 and a second loxP site was inserted downstream of exon 18. The neomycin resistance gene was removed via flp-mediated recombination leaving exons 4-18 floxed. (J:331744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2o Mutation: 57 strains or lines available

References

• Original: J:331744 Ma M, et al., UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination. Oncogene. 2022 Nov;41(48):5199-5213
• All: 1 reference(s)