Pdyn^tm1.1Tlk
Targeted Allele Detail

Summary

• Symbol: Pdyn^tm1.1Tlk
• Name: prodynorphin; targeted mutation 1.1, Thomas L Kash
• MGI ID: MGI:7407169
• Synonyms: Pdyn^lox
• Gene: Pdyn Location: Chr2:129528485-129541764 bp, - strand Genetic Position: Chr2, 63.19 cM
• Alliance: Pdyn^tm1.1Tlk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331789
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed the first coding exon. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the first coding exon (J:331789)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdyn Mutation: 20 strains or lines available

References

• Original: J:331789 Bloodgood DW, et al., Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake. Mol Psychiatry. 2021 Jun;26(6):2187-2199
• All: 4 reference(s)