Serpinb1a^tm1.2Cben
Targeted Allele Detail

Summary

• Symbol: Serpinb1a^tm1.2Cben
• Name: serine (or cysteine) peptidase inhibitor, clade B, member 1a; targeted mutation 2, Charaf Benarafa
• MGI ID: MGI:7407145
• Synonyms: Sb1a^F, Serpinb1a^{tm1.2(flox)Cben}
• Gene: Serpinb1a Location: Chr13:33026075-33035168 bp, - strand Genetic Position: Chr13, 13.75 cM, cytoband A4
• Alliance: Serpinb1a^tm1.2Cben page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308372
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was introduced into intron 6 and a floxed Hyg-TK selection cassette into intron 7. The selection cassette were removed by transient Cre expression, leaving a floxed exon 7. (J:308372)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpinb1a Mutation: 28 strains or lines available

References

• Original: J:308372 Burgener SS, et al., Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1. Biol Chem. 2016 Sep 1;397(9):897-905
• All: 1 reference(s)