Cbs^tm1.1Dee
Targeted Allele Detail

Summary

• Symbol: Cbs^tm1.1Dee
• Name: cystathionine beta-synthase; targeted mutation 1.1, Leo E Deelman
• MGI ID: MGI:7398608
• Gene: Cbs Location: Chr17:31831602-31856170 bp, - strand Genetic Position: Chr17, 16.93 cM, cytoband A-C
• Alliance: Cbs^tm1.1Dee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329962
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:329962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbs Mutation: 45 strains or lines available

References

• Original: J:329962 Nakladal D, et al., Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia. FASEB J. 2022 Apr;36(4):e22260
• All: 2 reference(s)