Dp(11Kcnj16-Kcnj2)7Smun
Allele Detail

Summary

• Symbol: Dp(11Kcnj16-Kcnj2)7Smun
• Name: duplication, Chr 11, Stefan Mundlos 7
• MGI ID: MGI:7398599
• Synonyms: Dup-K1
• Gene: Dp(11Kcnj16-Kcnj2)7Smun Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235642
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Other (Not Applicable)
• Mutations: Duplication, Insertion
• Dp(11Kcnj16-Kcnj2)7Smun involves 2 genes/genome features (Kcnj16, Kcnj2) View all
• Mutation details: This duplication allele was created through cre-mediated interchromosomal recombination between loxP sites on two alleles: allele Igs46^em1Smun containing a single loxP site at chr11:110801622-110801623 (GRCm39), the other a derivative of allele IIgs44^{tm1(sb-SBlac)Smun} where the SBlac transposon cassette was remobilized using the Tg(Prm1-sb16)AFsp allele and re-inserted at (hopped to) chr11:111403236-111403237. It duplicates around half of the Kcnj topologically associated domain (TAD) and the Kcnj16 and Kcnj2 genes it contains. (J:235642)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(11Kcnj16-Kcnj2)7Smun Mutation: 0 strains or lines available

References

• Original: J:235642 Franke M, et al., Formation of new chromatin domains determines pathogenicity of genomic duplications. Nature. 2016 Oct 13;538(7624):265-269
• All: 1 reference(s)