Stat3^em1Mcoo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stat3^em1Mcoo
• Name: signal transducer and activator of transcription 3; endonuclease-mediated mutation 1, Megan A Cooper
• MGI ID: MGI:7398577
• Synonyms: STAT3 GOF, Stat3^p.G421R
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^em1Mcoo page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/CAS9 technology, a single nucleotide change was introduced into the Stat3 gene to create a knock-in mouse model harboring a de novo pathogenic human STAT3 variant (p.G421R). (J:331798)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:331798 Schmitt EG, et al., A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice. JCI Insight. 2022 Nov 8;7(21)
• All: 1 reference(s)