Igs45^{tm1(sb-SBlac)Smun}
Targeted Allele Detail

Summary

• Symbol: Igs45^{tm1(sb-SBlac)Smun}
• Name: intergenic sequence 45; targeted mutation 1, Stefan Mundlos
• MGI ID: MGI:7398575
• Synonyms: SB-Sox9
• Gene: Igs45 Location: Chr11:112544204-112544205 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs45^{tm1(sb-SBlac)Smun} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235642
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter, Transposon concatemer)
• Mutation: Insertion
• Mutation details: The following cassette was inserted at chr11:112544204-112544205 (GRCm39) using homologous recombination: a Sleeping Beauty transposon inverted repeat, loxP site, human beta-globin HBB minimal promoter, the lacZ beta-galactosidase reporter gene, SV40 poly(A) signal sequence, and a Sleeping Beauty transposon direct repeat. (J:235642)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs45 Mutation: 0 strains or lines available

References

• Original: J:235642 Franke M, et al., Formation of new chromatin domains determines pathogenicity of genomic duplications. Nature. 2016 Oct 13;538(7624):265-269
• All: 2 reference(s)