Nr1d1^tm1.1Laz
Targeted Allele Detail

Summary

• Symbol: Nr1d1^tm1.1Laz
• Name: nuclear receptor subfamily 1, group D, member 1; targeted mutation 1.1, Mitchell A Lazar
• MGI ID: MGI:7398567
• Gene: Nr1d1 Location: Chr11:98658758-98666159 bp, - strand Genetic Position: Chr11, 62.66 cM
• Alliance: Nr1d1^tm1.1Laz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: ) targeting vector was designed to insert a loxP site upstream of exon 3 of the nuclear receptor subfamily 1 (Nr1d1) gene, and a FRT-flanked neomycin resistance cassette, followed by a second loxP site, was inserted downstream of exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:279241)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr1d1 Mutation: 44 strains or lines available

References

• Original: J:279241 Dierickx P, et al., SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12147-12152
• All: 7 reference(s)