Arhgef2^tm1.1Rtpl
Targeted Allele Detail

Summary

• Symbol: Arhgef2^tm1.1Rtpl
• Name: Rho/Rac guanine nucleotide exchange factor 2; targeted mutation 1.1, Robert Rottapel
• MGI ID: MGI:7398504
• Synonyms: Lfc KO
• Gene: Arhgef2 Location: Chr3:88513273-88555359 bp, + strand Genetic Position: Chr3, 38.9 cM, cytoband F1
• Alliance: Arhgef2^tm1.1Rtpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331752
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2, and a loxP-flanked neomycin resistance cassette (in reverse orientation) was inserted downstream of exon 2. Cre-mediated recombination in the germline resulted in this allele lacking both exon 2 and the floxed neo cassette. (J:331752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef2 Mutation: 77 strains or lines available

References

• Original: J:331752 Meiri D, et al., Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition. Mol Cell. 2012 Mar 9;45(5):642-55
• All: 4 reference(s)