Spink5^tm1.1Tyi
Targeted Allele Detail

Summary

• Symbol: Spink5^tm1.1Tyi
• Name: serine peptidase inhibitor, Kazal type 5; targeted mutation 1.1, Tangsheng Yi
• MGI ID: MGI:7398292
• Gene: Spink5 Location: Chr18:44096302-44155568 bp, + strand Genetic Position: Chr18, 23.74 cM
• Alliance: Spink5^tm1.1Tyi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331721
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A 688 bp region encompassing exon 2 was flanked by loxP sites (corresponding to chr18: 43,964,065-43,964,752). An inserted FRT-flanked PGK neomycin cassette was removed via adeno-flp-mediated recombination. (J:331721)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spink5 Mutation: 59 strains or lines available

References

• Original: J:331721 Jackman JK, et al., Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma. J Allergy Clin Immunol. 2022 Apr 26
• All: 2 reference(s)