Tg(Rr32-Thy1)#Rodh
Transgene Detail

Summary

• Symbol: Tg(Rr32-Thy1)#Rodh
• Name: transgene insertion, Robin D Hatton
• MGI ID: MGI:7397264
• Synonyms: Ifng-Thy1.1flCNS-22 BAC-In
• Transgene: Tg(Rr32-Thy1)#Rodh Location: unknown
• Alliance: Tg(Rr32-Thy1)#Rodh page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene insert consists of BAC clone RP24-348O11 where the Thy1 cDNA coding region and SV40 poly(A) signal sequence were inserted into Ifng exon 1 immediately downstream of the ATG start site (replacing the remainder of the exon 1 coding region), upstream Ifng cis-control region CNS-22 (Rr32) was flanked by loxP sites, and an FRT site flanked kanamycin resistance gene cassette was inserted between Rr32 and Ifng. The kana cassette was removed through subsequent flp-mediated recombination. (J:116207)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:116207 Hatton RD, et al., A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity. 2006 Nov;25(5):717-29
• All: 3 reference(s)