Rr149350^tm1.2Che
Targeted Allele Detail

Summary

• Symbol: Rr149350^tm1.2Che
• Name: regulatory region 149350; targeted mutation 1.2, Jianzhu Chen
• MGI ID: MGI:7388303
• Synonyms: deltaPDbeta1, K.O. (deltaneo)
• Gene: Rr149350 Location: Chr6:41509067-41510140 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr149350^tm1.2Che page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54060
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The 3kb KpnI-AccI restriction sequence containing DNAse1 hypersensitivity sites 9-11 upstream of Trbd1 which form or are part of its promoter/enhancer, was replaced with a loxP site flanked neomycin resistance gene cassette, sequence for prearranged segments Trbd1/Trbj2-5 and a third loxP site. The neo cassette and the inserted gene segments were removed through subsequent cre-mediated recombination. (J:54060)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr149350 Mutation: 0 strains or lines available

References

• Original: J:54060 Whitehurst CE, et al., Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter. Immunity. 1999 Mar;10(3):313-22
• All: 2 reference(s)