Daxx^em1Glo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Daxx^em1Glo
• Name: Fas death domain-associated protein; endonuclease-mediated mutation 1, Guillermina Lozano
• MGI ID: MGI:7388243
• Synonyms: Daxx^fl
• Gene: Daxx Location: Chr17:34128388-34134564 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Daxx^em1Glo page

Mutation origin

• Strain of Origin: 129-Daxx^tm2Led/J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted the missing nucleotide in the first loxP site that had been deleted in Daxx^tm2Led to generate a functional loxP site and thus conditional allele. (J:312564)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Daxx^em1Glo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Daxx Mutation: 34 strains or lines available

References

• Original: J:312564 Wasylishen AR, et al., Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. Sci Adv. 2020 Aug;6(32):eaba8415
• All: 2 reference(s)