Setd1a^em1Ashi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Setd1a^em1Ashi
• Name: SET domain containing 1A; endonuclease-mediated mutation 1, Ali Shilatifard
• MGI ID: MGI:7386869
• Synonyms: Set1A^{delta SET}, SETless
• Gene: Setd1a Location: Chr7:127376561-127399294 bp, + strand Genetic Position: Chr7, 69.73 cM
• Alliance: Setd1a^em1Ashi page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology targeted the SET domain of Setd1a inserting a two-nucleotide at the start of the SET domain in exon 17, resulting in an early stop codon that removes the majority of the SET domain (J:331091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd1a Mutation: 60 strains or lines available

References

• Original: J:331091 Cenik BK, et al., A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2118385119
• All: 1 reference(s)