Mpnd^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mpnd^em1(IMPC)J
• Name: MPN domain containing; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7384385
• Gene: Mpnd Location: Chr17:56316201-56323790 bp, + strand Genetic Position: Chr17, 29.11 cM, cytoband D
• Alliance: Mpnd^em1(IMPC)J page
• IMPC: Mpnd gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TGCCTGGACCAACCGCCAGA and ATCAGGATTCAGGATTCCCC, which resulted in a 389 bp deletion beginning at Chromosome 17 position 56,010,881 bp and ending after 56,011,269 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001271227 (exon 4) and 265 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 167 and early truncation 33 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mpnd Mutation: 23 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)